Here's some of the new information we've collected from the interview:

• Johnny was head of The Lost while Billy was incarcerated. When Billy comes back, Billy is not happy.
• The ending will have Niko and Johnny fighting with fists on top of a floating platform in a lava field.*
• When you get information, you will get a health boost and a couple of other things.
• There are mid-mission check-points.
• Johnny can use Love-Meet, you're not tied to your "old lady".
• One of the missions is where you use your grenade launcher and shoot though a Angel's of Death's club house and then you charge in.
• Multiplayer content will be talked about next week.
• When asked if there was a connection between Niko, Johnny, and Luis in the mission Museum Piece where you get the achievement "Impossible Trinity", pegging Luis as the possible main character for the next DLC, Jeronimo commented that "Those are some interesting dots to connect, that's all I'm going to say".

*Yes, we know they were joking.

If you didn't catch the interview on TV, you can see it now at GameTrailers.com.